Zolidd; improving implant stability

Zolidd is our first product based on the FibMat-technology. In Zolidd, the FibMat-coating is loaded with a bisphosphonate. Bisphosphonates are much used and since long approved drugs used to decrease bone resorption. By adding bisphosphonate drug to the FibMat coating, local resorption is reduced, and the bone surrounding the implant is made stronger. Enhancing the holding power is likely to reduce the risk of loosening and failure.
 

Improving implant stability

Worldwide usage of bone screws exceeds 100 million per year (estimation). This makes the bone screw the most commonly implanted device. Screw loosening in bone is a signinficant problem, for example in hip fractures, hip screw migration (“cut-out”) is about 3-10 %. In elderly, such an event may result in death due to complications of a second surgery to fix the problem.

This is a key user-need in CMF and traumatology, where devices fixed with screws are to be removed later. The need to remove screws may arise for a variety of reasons such as patient request, postoperative complication, or surgeon reimbursement for removal surgery.

Zolidd has given promising results in a dental study, and more clinical work is underway.

Zolidd is based on the FibMat technology platform

The FibMat technology is a proprietary platform for local application of drugs. Basically, it is a thin organic layer applied on an implant , enabling local presence of drugs. FibMat can be used with a variety of drugs on a wide range of implants. It is fully biocompatible, and is applied to implants in an industrial process. The FibMat matrix is invisible to the eye and only nanometers thin.
 

FibMat matrix is

• Biocompatible
• Resorbable
• Invisible

FibMat matrix can be

• Of desired thickness (10s of nanometers)    
• Loaded with a wide selection of drugs    
• Applied in an industrial process
• Gamma sterilized